Can You Overdose on Flexeril? Side Effects & Symptoms

Can You Overdose on Flexeril? Side Effects & Symptoms

If taking a single dose of extended-release formula, the average peak time is around 7 hours. For immediate-release cyclobenzaprine, peak time is around 4 hours. Dr. Cook, a licensed pharmacist, and two fourth-year PharmD students at the Ernest Mario School of Pharmacy conducted the study, which evaluated the weight variability of 90 cyclobenzaprine HCl 10 mg tablets.

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It may decrease the signals from your brain that tell your muscles to spasm. Cyclobenzaprine also comes as an oral extended-release capsule. Swallow the extended-release capsules whole; do not chew or crush them. Avoid driving or hazardous activity until you know how this medicine will affect you.

Cyclobenzaprine side effects

Cyclobenzaprine is a centrally acting skeletal-muscle relaxant, claimed to be effective in providing relief of muscle spasm, pain and tenderness, and in reducing the limitations imposed thereby on normal daily activities. It is structurally similar to the tricyclic antidepressants and adverse effects similar to those seen with the tricyclic antidepressants are therefore to be expected. This may place them at an increased risk of encountering side effects such as drowsiness and fatigue from too much medication, according to the study’s primary investigator. A post-marketing surveillance program was carried out in 7607 patients with acute musculoskeletal disorders, and included 297 patients treated with FLEXERIL 10 mg for 30 days or longer. The overall effectiveness of FLEXERIL was similar to that observed in the double-blind controlled studies; the overall incidence of adverse effects was less (see ADVERSE REACTIONS).

Protect the patient’s airway, establish an intravenous line and initiate gastric decontamination. Observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is necessary. If signs of toxicity occur at any time during this period, extended monitoring is required.

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This should include large volume gastric lavage followed by activated charcoal. If consciousness is impaired, the airway should be secured prior to lavage and emesis is contraindicated. In order to protect against the rare but potentially critical manifestations described above, obtain an ECG and immediately initiate cardiac monitoring.


Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended. The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies. provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.

Admitting your substance use has gotten out of control can save your life. Do not take more of it and do not take it more often than your doctor ordered. To do so may increase the chance of serious side effects.

  • If you notice any other effects, check with your healthcare professional.
  • Flexeril is usually taken once daily for only 2 or 3 weeks.
  • Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases.
  • It is very important that your doctor check your progress at regular visits.

Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. If you notice other effects not listed above, contact your doctor or pharmacist. The dosage is based on your medical condition and response to treatment. This medication should only be used short-term (for 3 weeks or less) unless directed by your doctor.

Symptoms of overdose may include the following:

RxList does not provide medical advice, diagnosis or treatment. At oral doses of up to 10 times the human dose, cyclobenzaprine did not adversely affect the reproductive performance or fertility of male or female rats. Cyclobenzaprine did not demonstrate mutagenic activity in the male mouse at dose levels of up to 20 times the human dose. For most patients, the recommended dose of Flexeril is 5 mg three times a day. Using Flexeril with other drugs that make you drowsy can worsen this effect. Flexeril is usually taken once daily for only 2 or 3 weeks.

Pharmacologic similarities among the tricyclic drugs require that certain withdrawal symptoms be considered when FLEXERIL is administered, even though they have not been reported to occur with this drug. Abrupt cessation of treatment after prolonged administration rarely may produce nausea, headache, and malaise. Flexeril is used together with rest and physical therapy to treat skeletal muscle conditions such as pain, injury, or spasms.